Tech Exchange with IVIM Technology

We are welcoming Pilhan Kim, Ph.D., Professor at the Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), and CEO/CTO of IVIM Technology, Inc..

Pilhan will speak about "All-in-One Real-time IntraVital Microscopy (IVM): In Vivo Cellular-level Imaging of Internal Organs in a Live Animal".

Intravital microscopy is a cutting-edge imaging technique to visualize various in vivo cellular-level dynamics interactions in a live animal. Intravital imaging of cellular dynamics in their native in vivo microenvironment can provide valuable insights in human diseases that are challenging to obtain through conventional histological observation of ex vivo sample or in vitro culture system. Over the past decade, the intravital microscopy has become an indispensable technique across diverse biomedical fields, including immunology, neuroscience, stem cell and tumor biology. Notably, in vivo visualizations of gene expression, protein activity, cell trafficking, cell-to-cell or cell-to-microenvironment interactions and various physiological responses to external stimuli have been successfully achieved. Furthermore, intravital microscopy now serves as a versatile platform for the development of new therapeutics and diagnostics by facilitating a direct in vivo observation of drug delivery to target cell and drug efficacy at the cellular level. It has enabled the detailed pharmacokinetic and pharmacodynamic analysis of various biopharmaceuticals, including antibodies, cell and gene therapy, nucleic acids, and exosome, within complex in vivo microenvironment.

In this talk, IVIM Technology’s All-in-One real-time intravital two-photon and confocal microscopy system will be introduced. The imaging system is extensively optimized for in vivo cellular-level imaging of internal organs in live animal model of human diseases. It can acquire a real-time, multi-color, sub-micron resolution images in a live animal model with automatic motion compensation function, which enables intravital imaging analysis of complex in vivo microenvironment comprising diverse types of cells such as stromal cells, immune cells, vascular cells and extracellular matrix. Intravital imaging of various organs including lung, heart, brain, liver, kidney, spleen, pancreas, small intestine, colon, lymph node, and bone marrow will be briefly introduced. Subsequently, recent studies employing intravital imaging technique to investigate dynamic cellular pathophysiology in human diseases and to develop novel therapeutics will be introduced.