Preclinical and Medical Imaging Technologies: use cases from our Nodes
MRI use cases
Anatomical, volumetric, morphometric MRI use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| Grey Matter Atrophy at Different Stages of Parkinson’s and Alzheimer’s Diseases | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1007/s10548-018-0675-2 |
| Effects of maternal perinatal stress/depression on young adult offspring | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1093/cercor/bhaa014 https://doi.org/10.1002/hbm.25163 |
| Differences in brain morphology between healthy subjects with and without déjà vu | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1016/j.cortex.2012.03.004 |
| Morphometry and gyrification in bipolar disorder and schizophrenia | Human | Brain Imaging Network (BIN) | https://doi.org/10.1016/j.nicl.2020.102220 |
| Whole brain longitudinal study in a mouse model of Huntington's disease | preclinical | Brain Imaging Network (BIN) | https://doi.org/10.1093/hmg/ddy119 |
| Neuroscience | Preclinical | Finnish Biomedical Imaging Node | https://doi.org/10.3389/fnins.2018.00668(neuroinflammation); https://doi.org/10.3389/fphar.2021.679759(neuronal activity) |
| Theranostics: MR monitoring the intratumor release of doxorubicin from liposomes stimulated by low intensity US | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1016/j.jconrel.2016.03.040 |
| Monitoring tumor onset, progression, metastatization and response to therapy | Preclinical | Molecular Imaging Italian Node | Prostate tumor treatment: http://dx.doi.org/10.1016/j.ejca.2014.06.014 CRC metastatis: https://doi.org/10.15252/emmm.201505395 |
| Evaluation of kidneys in polycystic kidney disease after treatment with 2-deoxy-glucose | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1681/ASN.2015030231 |
| Characterization of the proteomic profile of skeletal muscles of diet induced obesity animal models | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.3390/ijms22094680 |
| Head and Neck Veins of the Mouse | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1371/journal.pone.0129912 |
| Reproducibility of automatic MRI segmentation | Human | Molecular Imaging Italian Node | https://doi.org/10.1007/s00429-020-02172-w https://doi.org/10.1016/j.neuroimage.2020.116932 https://doi.org/10.1002/hbm.22859 |
| D-serine regulation in the brain | Preclinical | Israel BioImaging | https://doi.org/10.1073/pnas.1722677115 |
| Role of Heparanase2 in pancreatic cancer growth | Preclinical | Israel BioImaging | https://doi.org/10.1016/j.matbio.2021.03.002 |
| Mapping fetal-placental oxygen-hemoglobin affinity in pregnant mice | Preclinical | Israel BioImaging | https://doi.org/10.1148/radiol.2015150721 |
| Ex-vivo MRI of spinal cords from pig models of spine injury | Ex-vivo | NORMOLIM | https://doi.org/10.1242/dmm.049053 |
| HF MRI visualisation of anatomically important landmarks of the anterior and posterior parts of the upper orbit | Ex-vivo | NORMOLIM | https://doi.org/10.3109/2000656x.2015.1041969 |
| Therapy monitoring in a patient-derived glioblastoma model | Preclinical | NORMOLIM | https://doi.org/10.7150/ntno.31479 |
| Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model | Preclinical | NORMOLIM | https://doi.org/10.1371/journal.pone.0191102 |
| MRI monitoring and characterization of joint damage in a mouse model of rheumatoid Arthritis | Preclinical | HU Med & Preclinical Node | https://doi.org/10.3390/ijms22041682 |
| Monitoring of demyelination after administration of cuprizone in mice | Preclinical | HU Med & Preclinical Node | https://doi.org/10.3390/cells9010081 https://doi.org/10.1016/j.jneuroim.2018.03.020 |
| Measurement of Cortical Thickness and Hippocampal Volumefor the evaluation of the preventive effect of exercise and oral branched-chain amino acid supplementation on obesity-induced brain changes in mice | Preclinical | PRIME | https://doi.org/10.3390/nu15071716 |
Relaxation mapping use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| Cortical gray matter, cerebellar, and white matter alterations in progressive multiple sclerosis | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.3389/fnins.2021.711067 |
| Contrast agent development | Preclinical | Finnish Biomedical Imaging Node | https://doi.org/10.1155/2019/5629597 https://doi.org/10.1002/cplu.202000190 |
| Parenchymal Spin-Lock fMRI Signals Depression in the rat brain associated to Cortical Spreading Depression | Preclinical | Finnish Biomedical Imaging Node | https://doi.org/10.1038/jcbfm.2014.16 |
| The shortening of relaxation time of phosphor metabolites as a biomarker for breast cancer | Human, high field | HF MRI Dutch Hub | https://doi.org/10.1002/nbm.4011 |
| Inflammation in the brain induced by ocular surface injury evaluated by relaxation mapping after injection of USPIO nanoparticles | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1167/iovs.14-13984 |
| Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1155/2014/879703 |
| Probe development: Superparamagnetic Iron Oxide Nanoparticles (SPION) | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1039/C5NR08486E https://doi.org/10.1039/C5NR01148E https://doi.org/10.1016/j.actbio.2018.04.040 |
| Probe development: Copper Oxide nanoparticles | In vitro | Israel BioImaging | https://doi.org/10.1088/0031-9155/60/15/5767 |
Microstructural/diffusion MRI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| White matter and basal ganglia microstructure in Parkinson's disease | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1016/j.parkreldis.2020.10.032 |
| Impact of dance intervention on brain structural integrity | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1155/2020/8836925 |
| Relation of the hippocampus microstructure with visuospatial scene and face category processing | Human | Brain Imaging Network (BIN) | https://doi.org/10.1002/brb3.2127 |
| Rodent brain edema | Preclinical | CAPI Node | https://doi.org/10.33549/physiolres.934460 |
| Angiogenesis in a GBM mouse model | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1016/j.nbd.2019.104705 |
| neurodegeneration in demyelinating disorders | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1172/JCI145071 |
| Graph metrics of structural brain networks | Human | Molecular Imaging Italian Node | https://doi.org/10.1089/brain.2021.0123 |
| Study of stress-induced microstructural alterations affecting the cognitive performance of rats via diffusion tensor MRI | Preclinical | HU Med & Preclinical Node | https://doi.org/10.3389/fnins.2020.00474 |
Perfusion MRI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| Epilepsy | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1038/s41598-021-89774-4 |
| Human brain vascular alterations induced by type 2 diabetes | Human | Brain Imaging Network (BIN) | https://doi.org/10.1038/jcbfm.2015.106 |
| DCE-MRI to investigate relationship between tumor vascularization in imatinib resistance in GIST mouse models | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1007/s10120... |
| Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1002/ijc.30073 |
| Evaluation of tissue damage and regeneration in a mouse model of critical limb ischemia | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1371/journal.pone.0142111 |
| Ovarian graft reception | Preclinical | Israel BioImaging | https://doi.org/10.1016/j.fertnstert.2013.10.007 |
| DCE-MRI to study the Blood-brain barrier function associated to drug delivery in mice models of brain metastasis | Preclinical | NORMOLIM | https://doi.org/10.1158/1535-7163.MCT-19-0160 https://doi.org/10.3390/ijms20174235 https://doi.org/10.3390%2Fnano11051140 https://doi.org/10.1016/j.jconrel.2018.11.029 |
| Arterial Spin Labelling for the evaluation of the preventive effect of exercise and oral branched-chain amino acid supplementation on obesity-induced brain changes in mice | Preclinical | PRIME | https://doi.org/10.3390/nu15071716 |
Functional MRI Use cases
CEST/MT MRI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| pH in breast cancer | Human, high field | Dutch HF MR Hub | https://doi.org/10.1002/nbm.4110 |
| MT and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats | Preclinical | Finnish Biomedical Imaging Node | https://doi.org/10.3389/fnins.2021.723831 |
| Tumour acidosis in mouse models | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1038/s41416-020-01173-0 https://doi.org/10.3390/cancers14194916 |
| Assessment of renal functionality in acute kidney ischemia-reperfusion injury in murine model | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1002/nbm.4287 |
| CEST agents: GlucoCEST and LipoCEST | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1002/nbm.4602 https://doi.org/10.1002/anie.201912327 |
MRS/MRSI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| In vivo molecular signatures of cervical spinal cord pathology in degenerative compression | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1089/neu.2021.0151 |
| Investigation of the GABA metabolism | Human | Brain Imaging Network | https://doi.org/10.1212/wnl.0000000000003044 https://doi.org/10.1371/journal.pone.0240907 |
| Whole brain longitudinal study in a mouse model of Huntington's disease | Preclinical | Brain Imaging Network (BIN) | https://doi.org/10.1093/hmg/ddy119 |
| Brain MRI and MRSI with lipid suppression | Human, high field | HF MR Dutch Hub | https://doi.org/10.1002/mrm.25331 |
| Neurochemical abnormalities in a mouse model of human chorea-acanthocytosis | Preclinical | Molecular Imaging Italian Node | 10.1186/s40478-021-01181-y |
| In vivo MRS of a mouse model of CDKL5 deficiency disorder (CDD) | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1111/jnc.15300 |
| In-vivo MRS to monitor brian glutamate and lactate level in a nerve agent intoxication model | Preclinical | Israel BioImaging | https://doi.org/10.3390/ijms16023226 |
Non hydrogen MRS/MRSI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| 19 F MRSI of capecitabine in the liver | Human, high field | HF MR Dutch Hub | https://doi.org/10.1002/nbm.3390 |
| 19F contrast agents development | Preclinical | CAPI Node | https://doi.org/10.1007/s10334-018-0721-9 |
| Imaging of inflammation using perfluorocarbon based contrast agents | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.3390/biomedicines9040379 |
| Tracking immune cell activity in mice by multispectral 19F-MRI | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1148/radiol.2019181073 |
| 19F contrast agents development: novel 19F MR based probe for Mn2+ detection | In vitro | Israel BioImaging | https://doi.org/10.1016/j.inoche.2017.02.008 |
| Deuterium metabolic imaging | Human, high field | Dutch HF MR Hub | https://doi.org/10.1002/nbm.4235 |
| SNR optimized 31P functional MRS to detect mitochondrial and extracellular pH change during visual stimulation | Human, high field | Dutch HF MR Hub | https://doi.org/10.1002/nbm.4137 |
| 31P spectroscopic imaging at 7 T in cancer patients | Human, high field | Dutch HF MR Hub | https://doi.org/10.1002/nbm.4204 https://doi.org/10.1002/nbm.4110 https://doi.org/10.1002/nbm.4086 |
| 23Na-MRI of knee cartilage | Human, high field | Dutch HF MR Hub | https://doi.org/10.1002/nbm.4173 |
| Glucose versus fructose metabolism in the mouse liver measured with deuterium metabolic imaging | Preclinical | PRIME | https://doi.org/10.3389/fphys.2023.1198578 |
Hyperpolarized MRI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| HP 13C-MRI of the kidney | Preclinical | Danish BioImaging | https://doi.org/10.1007/978-1-0716-0978-1_29 |
| Real-time cardiac metabolism assessed by HP 13C-MRI | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1016/j.jcmg.2012.11.023 https://doi.org/10.1002/cmmi.1618 |
Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| Quantitative and volumetric MRI study to elucidate the possible mechanism of extrapyramidal damage in Fabry Disease | Human | Molecular Imaging Italian Node | https://doi.org/10.1016/j.parkreldis.2018.07.011 |
| Brain imaging | Human | Israel BioImaging | - |
| Cerebral Microbleeds in rats | Preclinical | HU Med & Preclinical Node | https://doi.org/10.1089/neu.2018.6004 |
Cardiovascular MRI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| Left atrial dysfunction in type 2 diabetes mellitus | Human | Brain Imaging Network (BIN) | https://doi.org/10.1007/s00330-014-3299-2 |
| Cardiac phenotypic components of human type 2 diabetes in a rat model | Preclinical | Brain Imaging Network (BIN) | https://doi.org/10.1016/j.jdiacomp.2020.107554 |
| Functional cardiac MRI | Human, high field | HF MR Dutch Hub | https://doi.org/10.1007/s10334-017-0665-5 |
| Imaging of Dysfunctional Elastogenesis in Atherosclerosis | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1021/acs.jmedchem.1c01286 |
| Characterization of left ventricle in a mouse model of acute ischemia-reperfusion injury | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1016/j.mri.2020.01.015 |
| MRI of atherosclerotic plaques | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1038/srep29353 |
| Effect of c-Jun dimerization protein 2 (JDP2) deficiency on the heart | Preclinical | Israel BioImaging | https://doi.org/10.1016/j.ijcard.2017.08.074 |
| Tissue phase mapping magnetic resonance imaging in rats | Preclinical | NORMOLIM | https://doi.org/10.1371/journal.pone.0247826 https://doi.org/10.1371%2Fjournal.pone.0218874 |
| A novel magnetic resonance imaging method for measurement of right ventricular strain in rats | Preclinical | NORMOLIM | https://doi.org/10.1152/ajpheart.00357.2019 |
| Cardiac morphology in atlantic salmon | Preclinical | NORMOLIM | http://dx.doi.org/10.1016/j.aquaculture.2020.735615 |
| High-field magnetic resonance elastography of rodent cardiac phantoms | Preclinical | NORMOLIM | https://doi.org/10.1016/j.jmbbm.2022.105302 |
| Response to treatment of heart failure and cardiac fibrosis monitored through cine-MRI | Preclinical | NORMOLIM | https://doi.org/10.1093/cvr/cvad078 |
| CMR imaging for studying how Imatimib attenuates reperfusion injusry in a rat model of acute myocardial infarction | Preclinical | PRIME | https://doi.org/10.1007/s00395-022-00974-z |
In vivo Optical Imaging (OI) use cases
Fluorescence in vivo Imaging (NIR I, NIR II) use cases
| Use case | Node | DOI |
|---|---|---|
| In vivo fluorescence imaging of transplanted human mesenchymal stromal cells by the use of biocompatible quaternized carbon dots | CAPI Node | https://doi.org/DOI:10.1016/j.... |
| Ex-vivo and in-vivo tumor targeting and imaging with octeotride conjugates | Finnish Biomedical Imaging Node | https://doi.org/10.3390/pharma... |
| In situ analysis of mice brains after intracisternal delivery of PEG-coated gold nanoparticles (potential drug or radioisotope carriers) to evaluate their brain penetrance, stability and cell specificity. | Molecular Imaging Italian Node | https://doi.org/10.1186/s12951... |
| Study of the therapeutic regeneration of lymphatic and immune cell functions upon lympho-organoid (LO) transplantation in mice models. NIR fluorescence imaging used to evaluate the lymphatic vasculature and drainage in the region of the LO transfer | Molecular Imaging Italian Node | https://doi.org/10.1016/j.stem... |
| Monitoring the fate of mesenchymal stem cells (MSCs) after transplantation in mice | Molecular Imaging Italian Node | https://doi.org/10.1002/jbio... |
| Targeted imaging and inhibition of triple-negative breast cancer using a PDGFRβ aptamer | Molecular Imaging Italian Node | https://doi.org/10.7150/thno... https://doi.org/10.7150/thno... |
| Studies of the lymph and vascular systems | Danish BioImaging | |
| whole-body distribution of labeled Hemoglobine proteins monitored by FLI | HU Med & Preclinical Node | https://doi.org/10.1016/j.freeradbiomed... |
| FLI to monitor the effect of photodynamic therapy of prostate cancer using a theranostic PSMA-targeting ligand | PRIME | https://doi.org/10.1007/s00259-023-06224-1 |
BioLuminescence Imaging (BLI) use cases
| Use case | Node | DOI |
|---|---|---|
| Biodistribution, oncology, cell tracking | CAPI Node | |
| Investigation of the protective role of BoxA for malignant mesothelioma treatment in a murine model, using ultrasound and optical imaging for detecting and monitoring peritoneal implants of mesothelioma cells | Molecular Imaging Italian Node | https://doi.org/10.1186/s41747... https://doi.org/10.1038/srep2285 |
| Biodistribution of Extracellular Vesicles Containing IL-4 used to Modulate Neuroinflammation in a Mouse Model of Multiple Sclerosis | Molecular Imaging Italian Node | https://doi.org/10.1016/j.ymthe... |
| In vivo study of Hypoxia inducible factor-1α inhibition on leukemia progression | Molecular Imaging Italian Node | https://doi.org/10.18632/oncot.. |
| Follow up of myeloma progression after treatment | Molecular Imaging Italian Node | https://doi.org/10.1182/blood... https://doi.org/10.1038/s41375... |
| Fluorescence and Luminescence imaging of ankle joints in a mouse model of Rheumatoid Arthritis for the assessment of plasma extravasation, vascular permeability and free radical production | HU Med & Preclinical Node | https://doi.org/10.3390/ijms... |
| Assessment of in vivo functionality of a novel Target Module with extended half-life targeting the tumor-associated carbohydrate sialyl-Tn through BLI | HU Med & Preclinical Node | https://doi.org/10.1186/s13046... |
| Pharmacokinetics of Iron-Doped Copper Oxide Nanoparticles for Nanomedical Applications | Flanders BioImaging | https://doi.org/10.1002/anie.201912312 |
Cerenkov Radiation Imaging and Radio Luminescence Imaging use cases
| Use case | Node | DOI |
|---|---|---|
| Evaluation of a new bimodal immunoradiotherapy treatment on mice with EL4 lymphoma | CAPI Node | https://doi.org/10.1016/j.jconrel... |
| Localization of T-cells marked with radionuclides for cancer immunotherapy in small animal rodents | Molecular Imaging Italian Node | https://doi.org/10.1002/jbio... |
| Nanoparticles for Cerenkov imaging and radiotherapy | Molecular Imaging Italian Node | https://doi.org/10.3390/nano... https://doi.org/10.3389/fchem... |
| 32P-ATP as a novel theranostic radiopharmaceutical for tracing tumor lesions while simultaneously hampering their growth | Molecular Imaging Italian Node | https://doi.org/doi:10.7150/thno... |
| Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery | Molecular Imaging Italian Node | https://doi.org/10.1117/1.JBO... |
US Imaging use cases
B-Mode (2D, 3D, 4D) US use cases
| Use case | Node | DOI |
|---|---|---|
| Tumor imaging, US guided drug administration | CAPI Node | |
| Echocardiography in pig models of chronic Myocardial Infarction | Finnish Biomedical Imaging Node | https://doi.org/10.1186/s12947... |
| Detection and quantification of vascular structures | Molecular Imaging Italian Node | https://doi.org/10.1002/sctm... https://doi.org/10.3390/ijms... https://doi.org/10.1177/1933... |
| Bladder thickness measurement after radiation therapy to predict radiation cystitis | Molecular Imaging Italian Node | https://doi.org/10.1186/s13014... |
| Tumor staging and monitoring after treatment | Molecular Imaging Italian Node | https://doi.org/10.1093/carcin... https://doi.org/10.3390/cancers... https://doi.org/10.1038/s4... |
| Characterization of Animal Models | Molecular Imaging Italian Node | https://doi.org/10.1155/2018... https://doi.org/10.1038/ijo... |
| Imaging guided injection; 3D and 4D cardiac imaging; Kidney tumors | Israel BioImaging |
Color Doppler, Power Doppler (2D, 3D) US use cases
| Use case | Node | DOI |
|---|---|---|
| Postoperative Monitoring of Vascularized Lymph Node Transfer | CAPI Node | submitted article |
| Monitoring the effect of paramylon nanofibers on liver damages induced by CCl4 | Molecular Imaging Italian Node | https://doi.org/10.1016/j.jff... |
| Investigation of high-fat-diet-induced alteration in vascular parameters in ApoE -/- mice | Molecular Imaging Italian Node | https://doi.org/10.1016/j.ultras... |
| Ecocardiography and cardiac MRI in mice reveals beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice | NORMOLIM | https://doi.org/10.1152/ajpheart... |
| Ecocardiography and MRI used to characterize a mouse model prepared through a new method for high precision aortic constriction | NORMOLIM | https://doi.org/10.1093/cvr... |
Non-Linear Contrast Mode US use cases
| Use case | Node | DOI |
|---|---|---|
| Cardio-imaging | CAPI Node | |
| Tumor angiogenesis | Molecular Imaging Italian Node | https://doi.org/10.1158/0008-5472... https://doi.org/10.18632/onco... |
| Evaluation of ovarian damage induced by chemotherapy | Molecular Imaging Italian Node | https://doi.org/10.1186/s41747... |
| Characterization of a murine model of human mesothelioma | Molecular Imaging Italian Node | https://doi.org/10.1038/srep22850 |
US volumetric analysis use cases
| Use case | Node | DOI |
|---|---|---|
| Quantitative In Vivo Monitoring of Hypoxia and Vascularization of Mantle Cell Lymphoma | CAPI Node | https://doi.org/10.1016/j.ultrasmedbio.... |
| cardiovascular studies | Danish BioImaging |
CT use cases
Standard CT
| Use case | Node | DOI |
|---|---|---|
| Photon Counting CT: ifferences between soft tissue types measured based on their spectral response, without contrast agents | CAPI Node | https://doi.org/10.1088/1748-0221... |
| Plant imaging | Finnish Biomedical Imaging Node | https://doi.org/10.1073/pnas... |
| Archaeology: annual growth of tooth-roth cementum in early Jurassic stem-mammals measured to evaluate their lifespans | Finnish Biomedical Imaging Node | https://doi.org/10.1038/s41467... |
| Lung/cardiac-gated in vivo micro-CT, brain, whole body of rodents | Finnish Biomedical Imaging Node | |
| Evaluation of ossification / bone regeneration in mice / rats models | Molecular Imaging Italian Node | https://doi.org/10.1242/dmm... https://doi.org/10.1371/journal... https://doi.org/10.3390/ijm... |
| Biodistribution of Au–Fe Alloy Nanoparticles | Molecular Imaging Italian Node | https://doi.org/10.1021/acsnano... |
| Coronary artery profiling in preclinical models | Molecular Imaging Italian Node | https://doi.org/10.3233/thc... |
| Evaluation of fat content | HU Med & Preclinical Node | https://doi.org/10.1111/bph... https://doi.org/10.1152/ajpheart... |
| Bone pathology in mouse models of neuronopathic Gaucher disease | Israel BioImaging | |
| Characterization of 3D-printed polyester scaffolds for soft tissue regeneration | Israel BioImaging | https://doi.org/10.1016/j.biomaterials... |
| Monitoring the development of lung pathology after challenge with SARS-CoV-2 in hamsters | Flanders BioImaging | https://doi.org/10.1038/s41586-020-3035-9 |
Phase Contrast CT Imaging
| Use case | Node | DOI |
|---|---|---|
X-rays phase contrast 3D virtual histology | Phase Contrast Imaging Flagship Node Trieste | https://doi.org/10.1038/s41598-021-89841-w https://doi.org/10.3389/fgstr.2023.1283052 |
| Bone structure - evaluation of microdamages | Phase Contrast Imaging Flagship Node Trieste | https://doi.org/10.1016/j.engfracmech.2022.108582 https://doi.org/10.1016/j.matdes.2023.112087 |
| Assessment of multi-organ damage in multiple sclerosis | Phase Contrast Imaging Flagship Node Trieste | https://doi.org/10.1038/s42005-022-01070-3 |
| High resolution lung CT imaging | Phase Contrast Imaging Flagship Node Trieste | https://doi.org/10.1038/s41598-023-30870-y |
PhotoAcoustic Imaging (PAI) use cases
Single wavelength regime (2D, 3D) PAI use cases
| Use case | Node | DOI |
|---|---|---|
| Probe design: condensed clustered iron oxides for ultrahigh photothermal conversion and In vivo multimodal imaging for theranostic applications | CAPI Node | https://doi.org/10.1021/acsami... |
| Probe design: photoacoustic properties of polypyrrole nanoparticles | CAPI Node | https://doi.org/10.3390/nano11... |
| Large photoacoustic effect enhancement for Indocianine Green confined inside MCM-41 mesoporous silica nanoparticles | Molecular Imaging Italian Node | https://doi.org/10.1039... |
| A novel integrin-targeting probe for photoacoustic imaging of cancer | Molecular Imaging Italian Node | https://doi.org/10.1016/j.pacs... |
| PAI to monitor the effect of photodynamic therapy of prostate cancer using a theranostic PSMA-targeting ligand | PRIME | https://doi.org/10.1007/s00259-023-06224-1 |
Multi-wavelength Mode (2D, 3D) PAI use cases
| Use case | Node | DOI |
|---|---|---|
| Quantitative In Vivo Monitoring of Hypoxia and Vascularization of Patient-Derived Murine Xenografts of Mantle Cell Lymphoma | CAPI Node | https://doi.org/10.1016/j.... |
| Study of Lymphatic Regeneration in a Rat Vascularized Lymph Node Transfer Model: lymphatic drainage reestablishment evaluated by ultrasound-photoacoustic imaging | CAPI Node | https://doi.org/10.1055/... |
| Photoacoustic assessment of vascular volume during tumor growth | Molecular Imaging Italian Node | https://doi.org/10.1016/j... |
| A theranostic nanosystem based on indocyanine green covalently conjugated to mesoporous silica nanoparticles loaded with the anticancer drug mitoxantrone as an innovative photoacoustic probe | Molecular Imaging Italian Node | https://doi.org/10.1039/... |
| Evaluation of Endothelial Colony Forming Cells (ECFCs) as vehicles to deliver AuNPs to tumors using a human melanoma xenograft mouse model | Molecular Imaging Italian Node | https://doi.org/10.1002/advs... |
| Targeting breast cancer cells with albumin-modified melanin-silica hybrid nanoparticles | Molecular Imaging Italian Node | https://doi.org/10.3389/fbioe... |
Oxy-Hemo Mode (2D, 3D) PAI use cases
| Use cas | Node | DOI |
|---|---|---|
| Quantitative In Vivo Monitoring of Hypoxia and Vascularization of Patient-Derived Murine Xenografts of Mantle Cell Lymphoma | CAPI Node | https://doi.org/10.1016/j.ultrasmedbio... |
| Assessment of oxygenation state in tumor | Molecular Imaging Italian Node | https://doi.or/10.1021/acsnano... |
| Photoacoustic assessment of vascular volume during tumor growth | Molecular Imaging Italian Node | https://doi.org/10.1016/j.bio... |
| Polymeric micelles simultaneously loaded with gold nanorods (GNRs) and Adriamycin used as a novel | Molecular Imaging Italian Node | https://doi.org/10.2147/ijn... |
PAI volumetric analysis use cases
| Use cases | Node | DOI |
|---|---|---|
| Quantitative In Vivo Monitoring of Hypoxia and Vascularization of Patient-Derived Murine Xenografts of Mantle Cell Lymphoma | CAPI Node | https://doi.org/10.1016/j.ultra... |
Nuclear medicine (PET, SPECT and bimodal) tracers and use cases
PET/SPECT tracers available at our Nodes
Click here to download the list of available tracers and related use cases. If you do not find what you are looking for, please send a message to info@eurobioimaging.eu
PET/MRI use cases can be found here.