Preclinical and Medical Imaging Technologies: use cases from our Nodes
MRI use cases
Anatomical, volumetric, morphometric MRI use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| Grey Matter Atrophy at Different Stages of Parkinson’s and Alzheimer’s Diseases | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1007/s10548-018-0675-2 |
| Effects of maternal perinatal stress/depression on young adult offspring | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1093/cercor/bhaa014 https://doi.org/10.1002/hbm.25163 |
| Differences in brain morphology between healthy subjects with and without déjà vu | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1016/j.cortex.2012.03.004 |
| Morphometry and gyrification in bipolar disorder and schizophrenia | Human | Brain Imaging Network (BIN) | https://doi.org/10.1016/j.nicl.2020.102220 |
| Whole brain longitudinal study in a mouse model of Huntington's disease | preclinical | Brain Imaging Network (BIN) | https://doi.org/10.1093/hmg/ddy119 |
| Neuroscience | Preclinical | Finnish Biomedical Imaging Node | https://doi.org/10.3389/fnins.2018.00668(neuroinflammation); https://doi.org/10.3389/fphar.2021.679759(neuronal activity) |
| Theranostics: MR monitoring the intratumor release of doxorubicin from liposomes stimulated by low intensity US | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1016/j.jconrel.2016.03.040 |
| Monitoring tumor onset, progression, metastatization and response to therapy | Preclinical | Molecular Imaging Italian Node | Prostate tumor treatment: http://dx.doi.org/10.1016/j.ejca.2014.06.014 CRC metastatis: https://doi.org/10.15252/emmm.201505395 |
| Evaluation of kidneys in polycystic kidney disease after treatment with 2-deoxy-glucose | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1681/ASN.2015030231 |
| Characterization of the proteomic profile of skeletal muscles of diet induced obesity animal models | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.3390/ijms22094680 |
| Head and Neck Veins of the Mouse | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1371/journal.pone.0129912 |
| Reproducibility of automatic MRI segmentation | Human | Molecular Imaging Italian Node | https://doi.org/10.1007/s00429-020-02172-w https://doi.org/10.1016/j.neuroimage.2020.116932 https://doi.org/10.1002/hbm.22859 |
| D-serine regulation in the brain | Preclinical | Israel BioImaging | https://doi.org/10.1073/pnas.1722677115 |
| Role of Heparanase2 in pancreatic cancer growth | Preclinical | Israel BioImaging | https://doi.org/10.1016/j.matbio.2021.03.002 |
| Mapping fetal-placental oxygen-hemoglobin affinity in pregnant mice | Preclinical | Israel BioImaging | https://doi.org/10.1148/radiol.2015150721 |
| Ex-vivo MRI of spinal cords from pig models of spine injury | Ex-vivo | NORMOLIM | https://doi.org/10.1242/dmm.049053 |
| HF MRI visualisation of anatomically important landmarks of the anterior and posterior parts of the upper orbit | Ex-vivo | NORMOLIM | https://doi.org/10.3109/2000656x.2015.1041969 |
| Therapy monitoring in a patient-derived glioblastoma model | Preclinical | NORMOLIM | https://doi.org/10.7150/ntno.31479 |
| Ultrasound-mediated delivery and distribution of polymeric nanoparticles in the normal brain parenchyma of a metastatic brain tumour model | Preclinical | NORMOLIM | https://doi.org/10.1371/journal.pone.0191102 |
| MRI monitoring and characterization of joint damage in a mouse model of rheumatoid Arthritis | Preclinical | HU Med & Preclinical Node | https://doi.org/10.3390/ijms22041682 |
| Monitoring of demyelination after administration of cuprizone in mice | Preclinical | HU Med & Preclinical Node | https://doi.org/10.3390/cells9010081 https://doi.org/10.1016/j.jneuroim.2018.03.020 |
Relaxation mapping use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| Cortical gray matter, cerebellar, and white matter alterations in progressive multiple sclerosis | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.3389/fnins.2021.711067 |
| Contrast agent development | Preclinical | Finnish Biomedical Imaging Node | https://doi.org/10.1155/2019/5629597 https://doi.org/10.1002/cplu.202000190 |
| Parenchymal Spin-Lock fMRI Signals Depression in the rat brain associated to Cortical Spreading Depression | Preclinical | Finnish Biomedical Imaging Node | https://doi.org/10.1038/jcbfm.2014.16 |
| The shortening of relaxation time of phosphor metabolites as a biomarker for breast cancer | Human, high field | HF MRI Dutch Hub | https://doi.org/10.1002/nbm.4011 |
| Inflammation in the brain induced by ocular surface injury evaluated by relaxation mapping after injection of USPIO nanoparticles | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1167/iovs.14-13984 |
| Inflammation and Remodeling of the Skeletal Muscle in a Mouse Model of Antisynthetase Syndrome | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1155/2014/879703 |
| Probe development: Superparamagnetic Iron Oxide Nanoparticles (SPION) | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1039/C5NR08486E https://doi.org/10.1039/C5NR01148E https://doi.org/10.1016/j.actbio.2018.04.040 |
| Probe development: Copper Oxide nanoparticles | In vitro | Israel BioImaging | https://doi.org/10.1088/0031-9155/60/15/5767 |
Microstructural/diffusion MRI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| White matter and basal ganglia microstructure in Parkinson's disease | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1016/j.parkreldis.2020.10.032 |
| Impact of dance intervention on brain structural integrity | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1155/2020/8836925 |
| Relation of the hippocampus microstructure with visuospatial scene and face category processing | Human | Brain Imaging Network (BIN) | https://doi.org/10.1002/brb3.2127 |
| Rodent brain edema | Preclinical | CAPI Node | https://doi.org/10.33549/physiolres.934460 |
| Angiogenesis in a GBM mouse model | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1016/j.nbd.2019.104705 |
| neurodegeneration in demyelinating disorders | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1172/JCI145071 |
| Graph metrics of structural brain networks | Human | Molecular Imaging Italian Node | https://doi.org/10.1089/brain.2021.0123 |
| Study of stress-induced microstructural alterations affecting the cognitive performance of rats via diffusion tensor MRI | Preclinical | HU Med & Preclinical Node | https://doi.org/10.3389/fnins.2020.00474 |
Perfusion MRI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| Epilepsy | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1038/s41598-021-89774-4 |
| Human brain vascular alterations induced by type 2 diabetes | Human | Brain Imaging Network (BIN) | https://doi.org/10.1038/jcbfm.2015.106 |
| DCE-MRI to investigate relationship between tumor vascularization in imatinib resistance in GIST mouse models | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1007/s10120... |
| Functional imaging of the angiogenic switch in a transgenic mouse model of human breast cancer | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1002/ijc.30073 |
| Evaluation of tissue damage and regeneration in a mouse model of critical limb ischemia | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1371/journal.pone.0142111 |
| Ovarian graft reception | Preclinical | Israel BioImaging | https://doi.org/10.1016/j.fertnstert.2013.10.007 |
| DCE-MRI to study the Blood-brain barrier function associated to drug delivery in mice models of brain metastasis | Preclinical | NORMOLIM | https://doi.org/10.1158/1535-7163.MCT-19-0160 https://doi.org/10.3390/ijms20174235 https://doi.org/10.3390%2Fnano11051140 https://doi.org/10.1016/j.jconrel.2018.11.029 |
Functional MRI Use cases
CEST/MT MRI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| pH in breast cancer | Human, high field | Dutch HF MR Hub | https://doi.org/10.1002/nbm.4110 |
| MT and Diffusion Tensor MRI of Lysophosphatidylcholine Induced Demyelination and Remyelination in Rats | Preclinical | Finnish Biomedical Imaging Node | https://doi.org/10.3389/fnins.2021.723831 |
| Tumour acidosis in mouse models | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1038/s41416-020-01173-0 https://doi.org/10.3390/cancers14194916 |
| Assessment of renal functionality in acute kidney ischemia-reperfusion injury in murine model | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1002/nbm.4287 |
| CEST agents: GlucoCEST and LipoCEST | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1002/nbm.4602 https://doi.org/10.1002/anie.201912327 |
MRS/MRSI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| In vivo molecular signatures of cervical spinal cord pathology in degenerative compression | Human | ALM and Medical Imaging Node Brno | https://doi.org/10.1089/neu.2021.0151 |
| Investigation of the GABA metabolism | Human | Brain Imaging Network | https://doi.org/10.1212/wnl.0000000000003044 https://doi.org/10.1371/journal.pone.0240907 |
| Whole brain longitudinal study in a mouse model of Huntington's disease | Preclinical | Brain Imaging Network (BIN) | https://doi.org/10.1093/hmg/ddy119 |
| Brain MRI and MRSI with lipid suppression | Human, high field | HF MR Dutch Hub | https://doi.org/10.1002/mrm.25331 |
| Neurochemical abnormalities in a mouse model of human chorea-acanthocytosis | Preclinical | Molecular Imaging Italian Node | 10.1186/s40478-021-01181-y |
| In vivo MRS of a mouse model of CDKL5 deficiency disorder (CDD) | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1111/jnc.15300 |
| In-vivo MRS to monitor brian glutamate and lactate level in a nerve agent intoxication model | Preclinical | Israel BioImaging | https://doi.org/10.3390/ijms16023226 |
Non hydrogen MRS/MRSI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| 19 F MRSI of capecitabine in the liver | Human, high field | HF MR Dutch Hub | https://doi.org/10.1002/nbm.3390 |
| 19F contrast agents development | Preclinical | CAPI Node | https://doi.org/10.1007/s10334-018-0721-9 |
| Imaging of inflammation using perfluorocarbon based contrast agents | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.3390/biomedicines9040379 |
| Tracking immune cell activity in mice by multispectral 19F-MRI | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1148/radiol.2019181073 |
| 19F contrast agents development: novel 19F MR based probe for Mn2+ detection | In vitro | Israel BioImaging | https://doi.org/10.1016/j.inoche.2017.02.008 |
| Deuterium metabolic imaging | Human, high field | Dutch HF MR Hub | https://doi.org/10.1002/nbm.4235 |
| SNR optimized 31P functional MRS to detect mitochondrial and extracellular pH change during visual stimulation | Human, high field | Dutch HF MR Hub | https://doi.org/10.1002/nbm.4137 |
| 31P spectroscopic imaging at 7 T in cancer patients | Human, high field | Dutch HF MR Hub | https://doi.org/10.1002/nbm.4204 https://doi.org/10.1002/nbm.4110 https://doi.org/10.1002/nbm.4086 |
| 23Na-MRI of knee cartilage | Human, high field | Dutch HF MR Hub | https://doi.org/10.1002/nbm.4173 |
Hyperpolarized MRI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| HP 13C-MRI of the kidney | Preclinical | Danish BioImaging | https://doi.org/10.1007/978-1-0716-0978-1_29 |
| Real-time cardiac metabolism assessed by HP 13C-MRI | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1016/j.jcmg.2012.11.023 https://doi.org/10.1002/cmmi.1618 |
Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| Quantitative and volumetric MRI study to elucidate the possible mechanism of extrapyramidal damage in Fabry Disease | Human | Molecular Imaging Italian Node | https://doi.org/10.1016/j.parkreldis.2018.07.011 |
| Brain imaging | Human | Israel BioImaging | - |
| Cerebral Microbleeds in rats | Preclinical | HU Med & Preclinical Node | https://doi.org/10.1089/neu.2018.6004 |
Cardiovascular MRI Use cases
| Use case | Preclinical / ex-vivo / human | Node | DOI |
|---|---|---|---|
| Left atrial dysfunction in type 2 diabetes mellitus | Human | Brain Imaging Network (BIN) | https://doi.org/10.1007/s00330-014-3299-2 |
| Cardiac phenotypic components of human type 2 diabetes in a rat model | Preclinical | Brain Imaging Network (BIN) | https://doi.org/10.1016/j.jdiacomp.2020.107554 |
| Functional cardiac MRI | Human, high field | HF MR Dutch Hub | https://doi.org/10.1007/s10334-017-0665-5 |
| Imaging of Dysfunctional Elastogenesis in Atherosclerosis | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1021/acs.jmedchem.1c01286 |
| Characterization of left ventricle in a mouse model of acute ischemia-reperfusion injury | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1016/j.mri.2020.01.015 |
| MRI of atherosclerotic plaques | Preclinical | Molecular Imaging Italian Node | https://doi.org/10.1038/srep29353 |
| Effect of c-Jun dimerization protein 2 (JDP2) deficiency on the heart | Preclinical | Israel BioImaging | https://doi.org/10.1016/j.ijcard.2017.08.074 |
| Tissue phase mapping magnetic resonance imaging in rats | Preclinical | NORMOLIM | https://doi.org/10.1371/journal.pone.0247826 https://doi.org/10.1371%2Fjournal.pone.0218874 |
| A novel magnetic resonance imaging method for measurement of right ventricular strain in rats | Preclinical | NORMOLIM | https://doi.org/10.1152/ajpheart.00357.2019 |
| Cardiac morphology in atlantic salmon | Preclinical | NORMOLIM | http://dx.doi.org/10.1016/j.aquaculture.2020.735615 |
| High-field magnetic resonance elastography of rodent cardiac phantoms | Preclinical | NORMOLIM | https://doi.org/10.1016/j.jmbbm.2022.105302 |
| Response to treatment of heart failure and cardiac fibrosis monitored through cine-MRI | Preclinical | NORMOLIM | https://doi.org/10.1093/cvr/cvad078 |
In vivo Optical Imaging (OI) use cases
Fluorescence in vivo Imaging (NIR I, NIR II) use cases
| Use case | Node | DOI |
|---|---|---|
| In vivo fluorescence imaging of transplanted human mesenchymal stromal cells by the use of biocompatible quaternized carbon dots | CAPI Node | https://doi.org/DOI:10.1016/j.... |
| Ex-vivo and in-vivo tumor targeting and imaging with octeotride conjugates | Finnish Biomedical Imaging Node | https://doi.org/10.3390/pharma... |
| In situ analysis of mice brains after intracisternal delivery of PEG-coated gold nanoparticles (potential drug or radioisotope carriers) to evaluate their brain penetrance, stability and cell specificity. | Molecular Imaging Italian Node | https://doi.org/10.1186/s12951... |
| Study of the therapeutic regeneration of lymphatic and immune cell functions upon lympho-organoid (LO) transplantation in mice models. NIR fluorescence imaging used to evaluate the lymphatic vasculature and drainage in the region of the LO transfer | Molecular Imaging Italian Node | https://doi.org/10.1016/j.stem... |
| Monitoring the fate of mesenchymal stem cells (MSCs) after transplantation in mice | Molecular Imaging Italian Node | https://doi.org/10.1002/jbio... |
| Targeted imaging and inhibition of triple-negative breast cancer using a PDGFRβ aptamer | Molecular Imaging Italian Node | https://doi.org/10.7150/thno... https://doi.org/10.7150/thno... |
| Studies of the lymph and vascular systems | Danish BioImaging | |
| whole-body distribution of labeled Hemoglobine proteins monitored by FLI | HU Med & Preclinical Node | https://doi.org/10.1016/j.freeradbiomed... |
BioLuminescence Imaging (BLI) use cases
| Use case | Node | DOI |
|---|---|---|
| Biodistribution, oncology, cell tracking | CAPI Node | |
| Investigation of the protective role of BoxA for malignant mesothelioma treatment in a murine model, using ultrasound and optical imaging for detecting and monitoring peritoneal implants of mesothelioma cells | Molecular Imaging Italian Node | https://doi.org/10.1186/s41747... https://doi.org/10.1038/srep2285 |
| Biodistribution of Extracellular Vesicles Containing IL-4 used to Modulate Neuroinflammation in a Mouse Model of Multiple Sclerosis | Molecular Imaging Italian Node | https://doi.org/10.1016/j.ymthe... |
| In vivo study of Hypoxia inducible factor-1α inhibition on leukemia progression | Molecular Imaging Italian Node | https://doi.org/10.18632/oncot.. |
| Follow up of myeloma progression after treatment | Molecular Imaging Italian Node | https://doi.org/10.1182/blood... https://doi.org/10.1038/s41375... |
| Fluorescence and Luminescence imaging of ankle joints in a mouse model of Rheumatoid Arthritis for the assessment of plasma extravasation, vascular permeability and free radical production | HU Med & Preclinical Node | https://doi.org/10.3390/ijms... |
| Assessment of in vivo functionality of a novel Target Module with extended half-life targeting the tumor-associated carbohydrate sialyl-Tn through BLI | HU Med & Preclinical Node | https://doi.org/10.1186/s13046... |
| Pharmacokinetics of Iron-Doped Copper Oxide Nanoparticles for Nanomedical Applications | Flanders BioImaging | https://doi.org/10.1002/anie.201912312 |
Cerenkov Radiation Imaging and Radio Luminescence Imaging use cases
| Use case | Node | DOI |
|---|---|---|
| Evaluation of a new bimodal immunoradiotherapy treatment on mice with EL4 lymphoma | CAPI Node | https://doi.org/10.1016/j.jconrel... |
| Localization of T-cells marked with radionuclides for cancer immunotherapy in small animal rodents | Molecular Imaging Italian Node | https://doi.org/10.1002/jbio... |
| Nanoparticles for Cerenkov imaging and radiotherapy | Molecular Imaging Italian Node | https://doi.org/10.3390/nano... https://doi.org/10.3389/fchem... |
| 32P-ATP as a novel theranostic radiopharmaceutical for tracing tumor lesions while simultaneously hampering their growth | Molecular Imaging Italian Node | https://doi.org/doi:10.7150/thno... |
| Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery | Molecular Imaging Italian Node | https://doi.org/10.1117/1.JBO... |
US Imaging use cases
B-Mode (2D, 3D, 4D) US use cases
| Use case | Node | DOI |
|---|---|---|
| Tumor imaging, US guided drug administration | CAPI Node | |
| Echocardiography in pig models of chronic Myocardial Infarction | Finnish Biomedical Imaging Node | https://doi.org/10.1186/s12947... |
| Detection and quantification of vascular structures | Molecular Imaging Italian Node | https://doi.org/10.1002/sctm... https://doi.org/10.3390/ijms... https://doi.org/10.1177/1933... |
| Bladder thickness measurement after radiation therapy to predict radiation cystitis | Molecular Imaging Italian Node | https://doi.org/10.1186/s13014... |
| Tumor staging and monitoring after treatment | Molecular Imaging Italian Node | https://doi.org/10.1093/carcin... https://doi.org/10.3390/cancers... https://doi.org/10.1038/s4... |
| Characterization of Animal Models | Molecular Imaging Italian Node | https://doi.org/10.1155/2018... https://doi.org/10.1038/ijo... |
| Imaging guided injection; 3D and 4D cardiac imaging; Kidney tumors | Israel BioImaging |
Color Doppler, Power Doppler (2D, 3D) US use cases
| Use case | Node | DOI |
|---|---|---|
| Postoperative Monitoring of Vascularized Lymph Node Transfer | CAPI Node | submitted article |
| Monitoring the effect of paramylon nanofibers on liver damages induced by CCl4 | Molecular Imaging Italian Node | https://doi.org/10.1016/j.jff... |
| Investigation of high-fat-diet-induced alteration in vascular parameters in ApoE -/- mice | Molecular Imaging Italian Node | https://doi.org/10.1016/j.ultras... |
| Ecocardiography and cardiac MRI in mice reveals beneficial effects of exercise initiated before development of hypertrophic cardiomyopathy in genotype-positive mice | NORMOLIM | https://doi.org/10.1152/ajpheart... |
| Ecocardiography and MRI used to characterize a mouse model prepared through a new method for high precision aortic constriction | NORMOLIM | https://doi.org/10.1093/cvr... |
Non-Linear Contrast Mode US use cases
| Use case | Node | DOI |
|---|---|---|
| Cardio-imaging | CAPI Node | |
| Tumor angiogenesis | Molecular Imaging Italian Node | https://doi.org/10.1158/0008-5472... https://doi.org/10.18632/onco... |
| Evaluation of ovarian damage induced by chemotherapy | Molecular Imaging Italian Node | https://doi.org/10.1186/s41747... |
| Characterization of a murine model of human mesothelioma | Molecular Imaging Italian Node | https://doi.org/10.1038/srep22850 |
US volumetric analysis use cases
| Use case | Node | DOI |
|---|---|---|
| Quantitative In Vivo Monitoring of Hypoxia and Vascularization of Mantle Cell Lymphoma | CAPI Node | https://doi.org/10.1016/j.ultrasmedbio.... |
| cardiovascular studies | Danish BioImaging |
CT use cases
Standard CT
| Use case | Node | DOI |
|---|---|---|
| Photon Counting CT: ifferences between soft tissue types measured based on their spectral response, without contrast agents | CAPI Node | https://doi.org/10.1088/1748-0221... |
| Plant imaging | Finnish Biomedical Imaging Node | https://doi.org/10.1073/pnas... |
| Archaeology: annual growth of tooth-roth cementum in early Jurassic stem-mammals measured to evaluate their lifespans | Finnish Biomedical Imaging Node | https://doi.org/10.1038/s41467... |
| Lung/cardiac-gated in vivo micro-CT, brain, whole body of rodents | Finnish Biomedical Imaging Node | |
| Evaluation of ossification / bone regeneration in mice / rats models | Molecular Imaging Italian Node | https://doi.org/10.1242/dmm... https://doi.org/10.1371/journal... https://doi.org/10.3390/ijm... |
| Biodistribution of Au–Fe Alloy Nanoparticles | Molecular Imaging Italian Node | https://doi.org/10.1021/acsnano... |
| Coronary artery profiling in preclinical models | Molecular Imaging Italian Node | https://doi.org/10.3233/thc... |
| Evaluation of fat content | HU Med & Preclinical Node | https://doi.org/10.1111/bph... https://doi.org/10.1152/ajpheart... |
| Bone pathology in mouse models of neuronopathic Gaucher disease | Israel BioImaging | |
| Characterization of 3D-printed polyester scaffolds for soft tissue regeneration | Israel BioImaging | https://doi.org/10.1016/j.biomaterials... |
| Monitoring the development of lung pathology after challenge with SARS-CoV-2 in hamsters | Flanders BioImaging | https://doi.org/10.1038/s41586-020-3035-9 |
Phase Contrast CT Imaging
| Use case | Node | DOI |
|---|---|---|
X-rays phase contrast 3D virtual histology | Phase Contrast Imaging Flagship Node Trieste | https://doi.org/10.1038/s41598-021-89841-w https://doi.org/10.3389/fgstr.2023.1283052 |
| Bone structure - evaluation of microdamages | Phase Contrast Imaging Flagship Node Trieste | https://doi.org/10.1016/j.engfracmech.2022.108582 https://doi.org/10.1016/j.matdes.2023.112087 |
| Assessment of multi-organ damage in multiple sclerosis | Phase Contrast Imaging Flagship Node Trieste | https://doi.org/10.1038/s42005-022-01070-3 |
| High resolution lung CT imaging | Phase Contrast Imaging Flagship Node Trieste | https://doi.org/10.1038/s41598-023-30870-y |
PhotoAcoustic Imaging (PAI) use cases
Single wavelength regime (2D, 3D) PAI use cases
| Use case | Node | DOI |
|---|---|---|
| Probe design: condensed clustered iron oxides for ultrahigh photothermal conversion and In vivo multimodal imaging for theranostic applications | CAPI Node | https://doi.org/10.1021/acsami... |
| Probe design: photoacoustic properties of polypyrrole nanoparticles | CAPI Node | https://doi.org/10.3390/nano11... |
| Large photoacoustic effect enhancement for Indocianine Green confined inside MCM-41 mesoporous silica nanoparticles | Molecular Imaging Italian Node | https://doi.org/10.1039... |
| A novel integrin-targeting probe for photoacoustic imaging of cancer | Molecular Imaging Italian Node | https://doi.org/10.1016/j.pacs... |
Multi-wavelength Mode (2D, 3D) PAI use cases
| Use case | Node | DOI |
|---|---|---|
| Quantitative In Vivo Monitoring of Hypoxia and Vascularization of Patient-Derived Murine Xenografts of Mantle Cell Lymphoma | CAPI Node | https://doi.org/10.1016/j.... |
| Study of Lymphatic Regeneration in a Rat Vascularized Lymph Node Transfer Model: lymphatic drainage reestablishment evaluated by ultrasound-photoacoustic imaging | CAPI Node | https://doi.org/10.1055/... |
| Photoacoustic assessment of vascular volume during tumor growth | Molecular Imaging Italian Node | https://doi.org/10.1016/j... |
| A theranostic nanosystem based on indocyanine green covalently conjugated to mesoporous silica nanoparticles loaded with the anticancer drug mitoxantrone as an innovative photoacoustic probe | Molecular Imaging Italian Node | https://doi.org/10.1039/... |
| Evaluation of Endothelial Colony Forming Cells (ECFCs) as vehicles to deliver AuNPs to tumors using a human melanoma xenograft mouse model | Molecular Imaging Italian Node | https://doi.org/10.1002/advs... |
| Targeting breast cancer cells with albumin-modified melanin-silica hybrid nanoparticles | Molecular Imaging Italian Node | https://doi.org/10.3389/fbioe... |
Oxy-Hemo Mode (2D, 3D) PAI use cases
| Use cas | Node | DOI |
|---|---|---|
| Quantitative In Vivo Monitoring of Hypoxia and Vascularization of Patient-Derived Murine Xenografts of Mantle Cell Lymphoma | CAPI Node | https://doi.org/10.1016/j.ultrasmedbio... |
| Assessment of oxygenation state in tumor | Molecular Imaging Italian Node | https://doi.or/10.1021/acsnano... |
| Photoacoustic assessment of vascular volume during tumor growth | Molecular Imaging Italian Node | https://doi.org/10.1016/j.bio... |
| Polymeric micelles simultaneously loaded with gold nanorods (GNRs) and Adriamycin used as a novel | Molecular Imaging Italian Node | https://doi.org/10.2147/ijn... |
PAI volumetric analysis use cases
| Use cases | Node | DOI |
|---|---|---|
| Quantitative In Vivo Monitoring of Hypoxia and Vascularization of Patient-Derived Murine Xenografts of Mantle Cell Lymphoma | CAPI Node | https://doi.org/10.1016/j.ultra... |
Nuclear medicine (PET, SPECT and bimodal) tracers and use cases
PET/SPECT tracers available at our Nodes
Click here to download the list of available tracers. If you do not find what you are looking for, please send a message to info@eurobioimaging.eu
PET/MRI use cases can be found here.